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KMID : 0882420120830040494
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Korean Journal of Medicine
2012 Volume.83 No. 4 p.494 ~ p.497
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A Case of Hereditable Pulmonary Hypertension
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Kim Jin-Ho
Lee Seung-Jun
Lee Han-Cheol
Lee Jin-Young
Lee Young-Jae
Chung Wook-Jin
Chang Hyuk-Jae
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Abstract
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Pulmonary arterial hypertension is a rare life-threatening disorder. Inherited cases of this disorder are known as heritable pulmonary arterial hypertension. Familial cases of heritable pulmonary arterial hypertension are caused by germline mutations of the bone morphogenetic protein receptor type 2 gene (BMPR), a type II receptor of the TGF-beta superfamily. This has not been reported in Korea. We report the first case of familial hereditable pulmonary arterial hypertension in Korea. The family has a mutation in exon12 of the BMPR2 gene (c.2695C > T, p.R899X).
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KEYWORD
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Pulmonary arterial hypertension, Bone morphogenetic protein receptor, Type II
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